This study assessed how participation in a comprehensive outpatient Dialectical Behavior Therapy (DBT) program affected the incidence of suicide attempts and non‑suicidal self‑injury (NSSI) among a sample of adults diagnosed with Borderline Personality Disorder (BPD) in Egypt — a setting where DBT had not previously been studied. Twenty‑five BPD patients (4 males and 21 females) took part in the DBT program over the course of one year, during which incidences of suicide attempts and NSSI were calculated. Over the year, five patients (20%) attempted suicide again, with an average of one attempt per patient, and seven patients (28%) engaged in NSSI, with a total of 22 incidents and a mean of three incidents per patient. As this was the first study applying standard DBT in an Egyptian context with language and cultural differences compared to where DBT was originally developed, the authors reported that DBT appeared to be effective in reducing suicidal and self‑injurious behaviors among this outpatient BPD sample, supporting its applicability across diverse cultural settings.

This long‑term follow‑up study tracked 290 adults diagnosed with borderline personality disorder (BPD) and 72 comparison patients with other personality disorders over 24 years, measuring the prevalence of major depressive disorder (MDD) at regular intervals using structured clinical interviews. Results showed that people with BPD had a significantly higher prevalence of MDD over time compared with the comparison group, but in both groups the overall rate of major depression declined significantly across the 24 years. Among those who had MDD at the start, 93% experienced a two‑year remission by the final follow‑up. However, recurrences and new onsets of major depression were also common in both groups during the long‑term period. These measurable outcomes indicate that although depression is more prevalent in BPD and often returns or emerges anew, most individuals experience remission of major depressive episodes over extended follow‑up.

This case–control study compared 104 adolescents meeting criteria for borderline personality disorder (BPD) with 60 psychiatrically healthy adolescents to identify measurable risk factors associated with adolescent BPD. Researchers assessed childhood adversity and protective experiences using a structured interview and evaluated personality traits with the Five‑Factor Model measure. In simple comparisons, eight variables reflecting severity of childhood abuse and neglect, positive childhood relationships, childhood competence, and personality traits (including neuroticism) were linked to BPD status. In a combined statistical model, three variables remained significant predictors: greater severity of childhood neglect (especially emotional neglect), higher levels of neuroticism (the tendency toward negative emotions), and lower levels of childhood competence (such as adaptive functioning and achievements). These measurable factors showed higher odds of adolescent BPD independent of age and demographic differences, suggesting that emotional neglect, negative emotional temperament, and limited childhood competence are key risk factors in the development of BPD in adolescents.

This study compared 20 women diagnosed with borderline personality disorder (BPD) and 20 healthy women to understand brain responses when viewing negative versus neutral emotional stimuli and how this relates to their ability to accept negative emotions. Participants underwent functional MRI (fMRI) scanning while watching emotionally negative and neutral movie clips and completed a standardized measure of emotion acceptance. Measurable results showed that women with BPD exhibited significantly greater activation in several brain regions—including the frontostriatal network (such as the superior frontal gyrus and caudate), posterior cingulate cortex, and hippocampus—when processing negative emotions compared with healthy controls. Participants with BPD also reported lower levels of habitual emotion acceptance. Correlational analyses revealed that lower emotion acceptance scores were associated with greater activation in striatal brain areas during negative stimuli among the BPD group. These findings provide measurable evidence that reduced acceptance of negative emotions in BPD is linked with heightened neural responses to negative emotional information, suggesting emotion acceptance may be an important treatment target.